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Tuesday
Jan042011

Gene Variant Could Predict Chance of Depression

Photo Courtesy - Getty Images(ANN ARBOR, Mich.) -- Whether you roll with life's punches or become depressed in the face of stress may be determined, in part, by your genes, according to new research from the University of Michigan.

The study, published in the Archives of General Psychiatry Monday, examined evidence from 54 studies that identified a particular gene variant, often referred to as the depression gene, as a possible determinant in who will and who will not suffer from clinical depression.

Although the predictive power of the gene variant was recently called into question by a smaller 2009 meta-analysis of 14 studies, researchers argue that the gene, 5-HTTLPR, does, indeed, affect a patient's chances of developing depression.

"That [2009] meta-analysis has been criticized for many reasons, mostly because they only include a few of the studies out there on this gene," says Dr. Srijan Sen, assistant professor of psychiatry at the University of Michigan Medical School and co-author on the study.

"We did a meta-analysis of all 54 studies that exist and, overall, we found that the results support [the existence of the gene] pretty strongly."

Although Sen says the gene has a relatively small impact on chances of developing depression, he hopes that the meta-analysis will help fuel the discovery of other genetic variants that influence depression.

Copyright 2011 ABC News Radio

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