Entries in Anti-Aging (3)


Could Red Wine Be the Secret to Anti-Aging?

Stockbyte/Thinkstock(CAMBRIDGE, Mass.) -- Red wine, already linked to healthy hearts and protection against certain cancers, may slow down the aging process by activating a specific aging-related gene, says a new study.

Using mice, researchers looked at the effects of resveratrol, a compound found in red wine. It was previously found to protect against diseases often associated with aging, such as type 2 diabetes. They found that when the anti-aging gene, SIRT1, was turned off in mice, resveratrol offered none of its longevity benefits.

The compound, said co-author David Sinclair of Harvard Medical School, “revs up the battery packs of the cells—the mitochondria—and if we delete SIRT1 in mice, resveratrol doesn’t do that anymore.”

“The decline in batteries is a major factor that makes us susceptible to diseases. The cells have more energy and live longer,” he said. In addition, reversatrol contributes to longevity by mimicking the effects of diet and exercise.

“We do see the same protective effects in the animal as if they were on a very strict diet,” Sinclair said.

Some of Sinclair’s research had demonstrated the benefits of resveratrol on the SIRT1 pathway in other organisms, but a debate persisted over how it worked.

Other scientists argued that there must have been an explanation other than SIRT1 to account for their findings.

This study, he said, offers proof of the role SIRT1 plays in the relationship between resveratrol and aging, and could offer insight into how future anti-aging drugs may work.

But determining whether or not drinking some red wine will actually hold off old age is still a long way off. While there have been small studies examining the effects of resveratrol in humans, but so far, research has not shown how the compound affects people’s aging.

Copyright 2012 ABC News Radio


Fight Aging: Recommendations for Best Anti-Aging Makeup

Jupiterimages/Pixland(NEW YORK) -- There are plenty of products on the shelves that promise to cover up the signs of aging, but which ones are really worth your money?

Reporters at Good Housekeeping magazine spoke with dozens of dermatologists and makeup artists to determine the best anti-aging makeup to help dry skin, wrinkles, or an uneven complexion.

What Can You Do For Dry Skin? Nothing accentuates fine lines like dry skin does, but luckily, there's an easy fix.  Rosemary Ellis, the editor in chief of Good Housekeeping, recommends you use makeup that has moisturizing ingredients such as glycerin and hyaluronic acid.

If you have dry skin, avoid any products that have the word "matte" anywhere on the packaging. A matte finish highlights dryness.

Their pick: Stila Illuminating tinted moisturizer, SPF 20 ($32, Sephora).

If your skin is really dry, you should avoid any base makeup that contains salicylic acid because the exfoliator sweeps away skin's natural oils.

What Can You Do For Lines? Retinol is among the most popular of line correctors found in foundations and concealers. Adding this form of vitamin A to makeup may increase cell turnover and collagen production, which is the basis of de-wrinkling. Retinol can make your skin sensitive to sunlight, so if you use retinol, you must use a daily SPF product.

Their pick: L'Oreal Paris Visible Lift Serum Absolute SPF 17 ($15 in drugstores) has retinol and built-in sun protection.

Look For Peptides: Peptides are wrinkle-fighting proteins that are finding their way into makeup. They are key to collagen synthesis and they enhance the performance of antioxidants.

Their pick: Mary Kay Timewise Luminous-Wear Liquid Foundation ($20, provides a blend of peptides and antioxidants.

Choosing Foundations: Most anti-aging makeup contains light-reflecting particles that create an instant optical illusion. Look for sheer and creamy foundations. Powder can crease and cake up, calling attention to wrinkles.

What Can You Do About Age Spots? Age spots or dark spots can become pronounced with sun exposure. Whether you're dealing with one or both, SPF can be a valuable addition to your makeup collection. Start with a sheer, luminous foundation because tiny reflective particles are the instant antidote to dullness. Then, brush on a creamy concealer over pronounced splotches and pat it in with your finger. Dermatologists like soy as an ingredient for fading and brightening, and certain antioxidants -- such as goji berries -- boost the skin's radiance and natural UV defenses.

Their picks: Aveeno Positively Radiant Tinted Moisturizer SPF 30 ($15 in drugstores). Contains soy and light-reflecting mica and silica.

Maybelline New York Age Rewind the Eraser ($13 in drugstores.) This foundation contains SPF 18 and goji berries.

Copyright 2011 ABC News Radio

Fight Aging: Good Housekeeping's Recommendations for Best Anti-Aging Makeup


Aging Reversed in Mice, Say Scientists

Photo Courtesy - Getty Images(BOSTON) -- Scientists have turned back the clock in mice they engineered to age faster than normal, an advance they suggest is the first time aging in mice has been reversed.

Researchers at Harvard-affiliated medical centers genetically manipulated mice to age faster, and then used gene therapy to lengthen telomeres -- compounds found at the ends of strands of DNA -- which reversed age-related problems such as decreased brain function and infertility.

"We at best expected it to be a slowing of the process or perhaps an arresting of the process. We did not anticipate that it would be so dramatic a reversal in all of the problems that the animal was experiencing," said Dr. Ronald DiPinho, professor of medicine at Harvard University Medical School and co-author of the paper published Sunday in the journal Nature. "We were so struck by the findings that we rushed to get the study published."

A human cell holds 23 pairs of chromosomes, each containing protective caps at each end called telomeres. Enzymes called telomerases protect the telomeres and reduce DNA damage thought to contribute to tissue aging. But as we age, our cells produce less telomerase; telomeres are cut shorter and eventually fail to protect DNA from damage.

Researchers boosted telomerase in the mice cells -- which hold 20 pairs of chromosomes -- to prevent telomeres from getting shorter. They found restoring the enzyme not only stopped aging but revived failing organs and even restored dark fur to mice who had turned grey. DePinho said the mice that were equivalent to ages 80 to 90 in human years returned to the equivalent of middle age.

"This [research] indicates there's a point of return for these tissues," said DePinho. "The fact that you can bring a tissue to the brink and then bring it back this dramatically is remarkable."

Previous studies suggest that even in humans, shorter telomeres may be associated with age-related diseases such as heart disease and Alzheimer's disease.

In fact, the brains of the age-modified mice were 75 percent of the size of a normal brain, much as happens in a patient with Alzheimer's disease. But when researchers reactivated the telomerase, the brains returned to a normal size, according to the study.

The aging process is complex and telomeres are just one element that contributes to its course. But DePinho said this is one step in learning more about not only the slowing of aging, but also the reversal.

"Telomere dynamics in mice has taught us the role of telomeres in [diseases like] cancer and helped us better understand how to take advantage of these situations," said DePinho.

Still, DePinho said the research is an early look down the pipeline for subsequent studies. Researchers plan to study the potential benefits in normal aging in mice before understanding whether the process might work in humans.

"We want to understand what contribution this makes to the aging process in conjunction with other factors that are responsible for the aging process," said DePinho. "We need to do a more careful analysis of these tissues and their cells to ascertain whether or not we could further regulate the process."

Copyright 2010 ABC News Radio

ABC News Radio