Entries in Bone Fracture (2)


Could Face Wrinkles Determine Bone Fracture Risk?

Goodshoot/Thinkstock(BOSTON) -- A close look into a woman's wrinkles may predict her risk for bone fractures, according to new findings by Yale researchers.

The deeper the wrinkles and the softer the skin of post-menopausal women, the lower their bone density is likely to be, the study concluded.

The link between the two could be collagen, a type of protein found in both the skin and skeleton, according to Dr. Lubna Pal, a reproductive endocrinologist at Yale School of Medicine. Pal was the lead author of the study, which was presented Monday at the Endocrine Society's Annual Meeting in Boston.

"Early menopause is a dynamic phase for both the skeleton and skin," Pal said.

During menopause, the loss in collagen contributes to both wrinkles and lower bone density.

The study looked at 114 women who recently went through menopause. Pal and her colleagues measured the deepness of wrinkles and the toughness of skin in 11 areas on the face and neck. Those with the deeper wrinkles and softer skin had lower bone density than the others in the group.

"The worse the wrinkles, the lesser the bone density, and this relationship was independent of age or of factors known to influence bone mass," said Pal.

The researchers used bone density scans to confirm their findings.

The study was one in a larger clinical trial still underway to determine whether certain types of estrogen therapies will help women prevent bone density loss and potentially delay wrinkles.

"We know estrogen protects against bone loss, but does it protect against skin wrinkles?" said Pal.

Pal cautioned that the research is not about reversing the signs of aging. Instead, she said that the finding makes a stronger case that "skin reflects the health of the skeleton."

While lower bone density may be one risk factor for fractures, it doesn't mean that the women would go on to develop osteoporosis.

"We're not saying that those with wrinkles have bones that will crumple," said Pal. "We're seeing if things on the outside of us can indicate a risk to things inside of us."

This initial research could provide insight into an earlier detection of conditions such as osteopoenia -- a condition of brittle bones -- and perhaps even osteoporosis.

Copyright 2011 ABC News Radio


Risk of Broken Bones Increases with HIV

John Foxx/Thinkstock(DENVER) -- The risk of bone fractures is higher for people living with HIV, researchers say.

Benjamin Young, MD, PhD, of the Rocky Mountain Center for AIDS Research, Education and Services in Denver, and colleagues reported that because the patient's immune system is in such a vulnerable state -- or at its lowest CD4 count -- risk of bone fracture is much greater. 

The study found that fragility fractures at the wrist, vertebra and femoral neck appear to be the main prompts for the increased risk.  Authors of the study also saw an association between fracture risk and factors like old age, substance abuse, hepatitis C co-infection and diabetes.

After the analysis of approximately 120,000 veterans, a 2010 report also indicated HIV could be a risk factor for fragility fractures.

Dr. Young hopes that the study's findings will help to advance bone health management for HIV patients, noting that the current method of care for this problem "is not well defined and remains controversial."

Young and colleagues reported their findings online in Clinical Infectious Diseases.

Copyright 2011 ABC News Radio 

ABC News Radio