(LOS ANGELES) -- A new study indicates that regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) could be associated with greater chance of erectile dysfunction.
Common over-the-counter NSAIDs include acetylsalicylic acid (aspirin), ibuprofen (Advil) and naproxen (Aleve).
In the cross-sectional study in a large health care system, the rate of erectile dysfunction was 35.2 percent among middle-aged men who regularly took NSAIDs compared to only 24 percent among those who did not, reported Dr. Steven Jacobsen, director of research at Kaiser Permanente Southern California in Los Angeles, and colleagues.
After adjusting for other factors which included age, ethnicity and body mass index, study authors say the difference in percentages worked out to a 1.22-fold greater probability of erectile dysfunction for NSAID users, according to the study published online in the journal Urology.
"While this raises the question of the role of inflammation and COX pathways in erectile dysfunction etiology, we cannot exclude alternative explanations," the researchers wrote.
Jacobsen told MedPage Today that if the association is indeed true, then it may be time to discuss the risks and benefits of using NSAIDs, whether for prevention or for treatment of various ailments.
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