(KANSAS CITY) -- The Missouri parents of missing 10-month-old Lisa Irwin are growing more desperate while police combing the neighborhood and asking to search people's homes have no leads in what they describe as a rare but terrifying crime.
Speaking to GMA from outside their home in Kansas City Thursday morning, the girl's mother choked back tears and father Jeremy Irwin repeated their plea for anyone with information on their missing toddler to come forward.
Lisa's mother, Deborah Brandley, described exactly what happened the last time she saw her daughter:
"[She disappeared] between the time she went to bed and time I went to bed," she said through tears. "I gave her her bottle and put her to sleep, and that was the last when we last saw her."
Irwin, who lives with Deborah and her two other children from pervious relationships, described how he returned from work around 4 a.m.
"The windows were open and the lights were on, and she was nowhere to be found," he said. "We've been going over everything in our minds. We just don't have any idea."
Police Capt. Steve Young said there are no major leads in the case, while Kansas City police and FBI agents continued their investigation and search for the baby. More than 300 law officers have been using helicopters, all-terrain vehicles and door-to-door interviews in the search.
Speaking with ABC News, Lisa's grandmother, Melanie Irwin, pleaded for the girl's return. "Bring her back. We love her, everybody loves her," Irwin said. "She needs her family. She needs her family. They need her."
Lisa was last seen at 10:30 p.m. Monday asleep in her crib at her parents' home. When her father arrived home at 4 a.m. from an overnight shift as an electrician, he discovered that Lisa was missing. The parents immediately called police.
While police initially fixated on a window and screen in the bedroom that appeared to have been tampered with and might have been where a kidnapper entered and exited, they are not certain such was the case.
"We are interviewing family and friends just to eliminate everyone's that close to the family as suspects," Officer Darin Snapp said.
He described the family's neighborhood as a "middle-class, very quiet neighborhood."
Copyright 2011 ABC News Radio